This study explores a novel class of chromone-hydrazone derivatives, capitalizing on the chromone scaffold's well-established biological potential and hydrazone moieties' efficient probe for coordination. Through strategic condensation reactions with diverse hydrazine derivatives, we successfully functionalized the chromone core, resulting in a library of structurally varied chromone-hydrazones. Employing ¹H NMR, ¹³C NMR, and FT-IR spectroscopy, the synthesized compounds were meticulously characterized to confirm their structures and elucidate the influence of substituents. This detailed characterization provided insights into the electronic and steric effects imparted by different substituents on the chromone-hydrazone framework.

This work not only enriches the repertoire of chromone-based derivatives but also paves the way for future exploration of their functional applications. The structural diversity of these compounds holds promise for a wide range of applications, reflecting the versatile nature of the chromone scaffold. Notably, the newly synthesized chromone-hydrazones will be evaluated for their potential as chemosensors for metal ions, anions, and small pollutant/critical molecules. These investigations are expected to open exciting avenues for biological, environmental, and analytical applications, showcasing the practical utility of these derivatives in real-world scenarios. By expanding the understanding and application of chromone-hydrazone derivatives, this study sets the stage for innovative advancements in chemosensing technologies and beyond.