Glycyrrhiza glabra (licorice) belongs to the family Fabaceae and has a long story in traditional medicines and folk remedies to treat inflammation, arthritis, gastrointestinal problems and dyspepsia, Consequently, there is ongoing research into novel plants and herbal compounds possessing anti-inflammatory properties, aiming to uncover more potent alternatives while mitigating the potential toxicities associated with conventional anti-inflammatory medications.

The aim of the present study was to evaluate the anti-inflammatory activity of Hydroalcoholic extract of Glycyrrhiza glabra root, in order to find new and more effective agents for the treatment of degenerative and inflammatory diseases.

The activity of anti-inflammatory was assessed by the protein denaturation method using the standard drug Diclofenac.

The phytochemical constituents identified were flavonoids, alkaloids, phenols, saponins, steroids, and terpenoids, with flavonoids, alkaloids, and phenols being the most abundant.

The results showed that the Hydroalcoholic extract of G. glabra root have a very good inhibitory effect, with percentages of 81 %, at a concentration of 10 g/L compared to Diclofenac (61.3 %).

Hydroalcoholic extract of roots exhibit attractive property anti-inflammatory, which can be attributed to the presence of secondary metabolites of different classes of compounds and can therefore, be considered a promising candidate for future application as alternative therapeutic agents, particularly in the development of anti-inflammatory drugs.