Biophotonics as a highly interdisciplinary paradigm, which studies biological processes activated by light at the molecular, cellular or tissue level, is increasingly important in modern medicine for diagnosis and therapy. Originally designed for the use in electronic and optoelectronic devices, conjugated polymers (CPs) have emerged as one of the most appropriate agents for biophotonics.
For a better interaction with biological entities, attaching hydrophilic side chains to the conjugated backbone, resulting in a grafted topology with enhanced properties in terms of physiological stability and optical properties, can be a better alternative to CPs nanoparticles encapsulation in amphiphilic biocompatible matrix by nanoprecipitation.
Following this strategy, the present communication reports on synthesis and basic characterization of amphiphilic grafted poly(p-phenylene vinylene)s (g-PPVs), having hydrophilic side chains differing in length, chemical nature and attaching way.
g-PPVs were synthesized by the Suzuki-Heck cascade polycondensation of macromonomers derived from PEG or poly(2-alkyl-oxazolines) (POXA). Spectral methods (1H-NMR, IR) were applied for polymers’ structural characterization, whereas DLS and AFM microscopy were complementary used to characterize the size and shape of the micellar nanoparticles formed by spontaneous self-assembling in aqueous media.
The photophysical properties of the formed micelles were followed by UV-vis and fluorescence spectroscopy and the results were discussed in relation with their size, the nature and the attaching way of the side chains. Interestingly, while for the PEG side chains the emission maximum appeared in the yellow-green region, for the both types of POXA a blue shift was noticed besides a clusteroluminescence phenomenon.
