Previous Article in event
Next Article in event
Total Synthesis of Morphine- and Hasubanane Alkaloids
Published: 01 September 1997 by MDPI in The 1st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: (-)-Morphine, the main alkaloid of the opium poppy, remains one of the most important medicines for the treatment of severe pain and a true delight for synthetic chemists.1 In spite of its small size and long history, it is still considered to be an interesting target for chemical synthesis. (-)-Morphine and its synthetic precursors (-)-codeine and (-)-dihydrocodeinone feature a complicated network of three carbocycles and two heterocycles containing five vicinal stereocenters, four of which define ring junctures. Among these, the benzylic quaternary carbon deserves special attention.