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Synthesis of a Photolabile `Safety Catch' Linker of the 3'-Methoxybenzoin Type
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1  Combinatorial Chemistry - Core Technology Area - Novartis Pharma AG - CH-4002 Basel, Switzerland

Abstract: Solid supports carrying a photolabile linker of the 3'-methoxybenzoin type were prepared by a rapid solid phase synthesis method. Alternatively, the linker was preassembled in solution by a more lengthy procedure and then coupled onto polystyrene via its carboxymethyl handle. `Safety catch' linkers of this type are expected to play an important role for the preparation of combinatorial libraries suitable for a variety of miniaturized screening methods, where `reagentless' release of compounds from the carrier is crucial
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