Metal ions and metal-ion binding substances are crucial in various biological processes, and their rational design can be used to develop novel therapeutic drugs and diagnostic tools. Metal atoms are soluble in biological fluids due to their ability to easily lose electrons and form positively charged ions. Because of their electron deficiency they can interact with electron-rich biomolecules like proteins and DNA, and potentially participating in catalytic mechanism or stabilizing their tertiary or quaternary structures. Metal ions are important for cellular processes and biological functions in microorganisms. Antibacterial resistance is an increasingly major concern to global public health, requiring novel strategies to combat new resistance mechanisms emerging and spreading globally in infectious microbes. Inorganic and organometallic complexes offer an opportunity to develop novel antimicrobial agents due to their diverse three-dimensional shapes and extensive design options, which can impact factors like substitution kinetics, charge, lipophilicity, biological targets, and mechanisms of action. This paper explores the antibacterial activity of vanadium complexes. Research in this field focuses on the potential antibacterial activity of vanadium-based drugs. Vanadium is a well-known transition metal, and its complexes have been extensively studied for their medicinal properties. Vanadium complexes of 2-(salicylideneimine)benzimidazole, aminophen and bromosalycilaldehyde, dimalonitrial-based Schiff base, 1,2,4-triazole Schiff base, and fluoro-substituted Schiff base and vanadium stilbene complex, etc., exhibited antibacterial activity. Research on antimicrobial metallodrugs is crucial to combat antibiotic resistance, but mechanisms of toxicity remain uncertain, and limited in vivo data hinder further development due to limited bacterial targets. Future multidisciplinary research on vanadium complexes as antibacterial potential offers opportunities to explore biochemistry, design novel, and improve solubility, bioavailability, and toxicity and focus on developing novel strategies for targeting toxic metals and developing nanostructured antimicrobials for better understanding metal complex behaviour in living organisms.