Recent developments in additive manufacturing have resulted in a reduction in the costs and the level of complexity connected with the manufacturing of conformal cooling channels (CCCs). Conformal cooling channels, also known as CCCs, offer a higher level of cooling efficiency in the injection molding process when compared to the more traditional straight-drilled channels. The fundamental reason for this is that traditional machining processes do not have the potential to properly follow the contours of the molded form. However, CCCs are able to offer this capability. Using CCCs makes it possible to improve cycle times, achieve a more uniform temperature distribution, and reduce thermal strains and warpage. When it comes to developing a design that is both productive and cost-effective, computer-aided engineering (CAE) simulations are an absolute necessity nowadays. The primary purpose is to determine the optimum placements of CCCs, to improve temperature uniformity and reduce the amount of time that ejections take place (ejection duration). For the sake of future optimization techniques, it is possible to infer the practicability and potential usefulness of the design variables and parametrization that were accomplished in ANSYS Parametric Design Language (APDL). In fact, all the considered geometric/design variables present significant sensitivity in the studied CAE model.