Introduction: According to the World Health Organization, cardiovascular diseases are the leading cause of death globally, accounting for 31% of all deaths worldwide in 2016. In Brazil, Acute Myocardial Infarction stands out as the leading cause of mortality among cardiac pathologies in the country. Thus, it is crucial to identify the epidemiological profile of deaths to diagnose the challenges faced by the Brazilian healthcare system and to target public health measures toward the groups most affected by this condition. Methods: A cross-sectional, descriptive, and retrospective study was conducted on deaths caused by Acute Myocardial Infarction between January 2014 and December 2023 in Brazil. Secondary data were collected from the Department of Information and Informatics of the Unified Health System. Results: Between 2014 and 2023, 931,983 deaths from Acute Myocardial Infarction were recorded in Brazil, with an average of 93,198.3 deaths per year and minimal fluctuation in annual mortality rates. The most affected age group was 80 years and older, accounting for 26.74% of total deaths. Men were 145% more affected than women, while the most vulnerable population groups were White and Brown individuals, representing 51.84% and 37.03% of deaths, respectively. Additionally, approximately 50% of deaths occurred in hospital settings. Conclusions: A high number of deaths from Acute Myocardial Infarction has been observed in the past decade in Brazil. The annual average number of deaths, combined with the low fluctuation in mortality rates over the years, and the prevalence of hospital-based deaths, indicates significant public health challenges in addressing the high mortality associated with this condition. Furthermore, the epidemiological profile of patients—elderly White or Brown men aged 80 years or older—highlights the most vulnerable group to Acute Myocardial Infarction. It is therefore of utmost importance to direct collective health measures toward this population group.