High-Andean wetlands are crucial ecosystems for water regulation and carbon storage, whose long-term conservation requires a comprehensive understanding of their dynamics, especially in the context of climate change. In this framework, the present research aimed to evaluate vegetation behavior in response to climatic variables in eight high-Andean wetlands located in the upper, middle, and lower sections of the Estero Ortiga sub-basin, within the Santuario de la Naturaleza Los Nogales, Metropolitan Region, Chile, during the period 2017–2024. The time series of the NDVI and NDCI vegetation indexes derived from Sentinel-2 images (January 2017–September 2024) and climate data on temperature and precipitation obtained from the "ERA5-Land monthly averaged data" product (January 2016–September 2024) were used. The results revealed a progressive decrease in vegetation cover and chlorophyll content during the study period, with slopes of -2,04 x 10⁻⁵ for NDVI and -1,15 x 10⁻⁵ for NDCI. Correlation analysis showed a significant positive relationship between annual accumulated precipitation and average vegetation index values during the following summer. For NDVI, the correlation coefficient (R) ranged between 0,83 and 0,88, while for NDCI, R ranged between 0,84 and 0,9. To determine a healthy vegetation cover, NDVI values were reclassified for the dates corresponding to the maximum value recorded each year. This analysis revealed a reduction in healthy vegetation cover starting in 2020. These findings highlight the importance of annual accumulated precipitation for the maintenance of high-Andean wetlands and underscore the use of remote sensing tools for monitoring and designing management and conservation strategies for these ecosystems.