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Copper-Mediated Aerobic Synthesis of 3-Tosyl-1,2,3,4-Tetrahydroquinazoline from 2 Tosylaminomethylaniline and Methanol
Published: 31 October 2013 by MDPI in The 17th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: An investigation has shown that 2 tosylaminomethylaniline plays a dual role in the oxidative process of methanol to formaldehyde acting as N-donor ligand and nucleophile, which leads to 3-tosyl-1,2,3,4-tetrahydroquinazoline (1). This was characterized by using both spectroscopic and X-ray diffraction techniques.
Keywords: Tetrahydroquinazoline / Methanol oxidation / 2 Tosylaminomethylaniline / Copper