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Copper-Mediated Aerobic Synthesis of 3-Tosyl-1,2,3,4-Tetrahydroquinazoline from 2 Tosylaminomethylaniline and Methanol
* 1 , 1 , 1 , 1 , 1 , 2
1  Coordination and Supramolecular Chemistry Group (Suprametal), Institute of Materials (iMATUS), Department of Inorganic Chemistry, Faculty of Chemistry, Universidade de Santiago de Compostela, Avenida das Ciencias s/n, 15782 Santiago de Compostela, Spain
2  Centro Singular de Investigacion en Química Biológica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain.

Abstract: An investigation has shown that 2 tosylaminomethylaniline plays a dual role in the oxidative process of methanol to formaldehyde acting as N-donor ligand and nucleophile, which leads to 3-tosyl-1,2,3,4-tetrahydroquinazoline (1). This was characterized by using both spectroscopic and X-ray diffraction techniques.
Keywords: Tetrahydroquinazoline / Methanol oxidation / 2 Tosylaminomethylaniline / Copper