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Synthesis and Comparison of Anti-inflammatory Activity of Chrysin Derivatives
* 1 , 1 , 2
1  School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
2  on Duc Thang University, Ho Chi Minh City, Vietnam

Abstract: A series of five chrysin derivatives was synthesized and examinated for their antiinflammatory activities. The in vivo anti-inflammatory activity of synthetic compounds was carried out using the model of carrageenan induced mice paw edema. The results showed that methylation of 5,7- dihydroxyl groups of chrysin resulted to increase the in vivo bioactivity in comparison with the corresponding chrysin derivatives having two free hydroxyl groups. The introduction two halide groups into B ring at 6 and 8 positions of chrysin did not to improve any significant increase positive effect on the in vivo bioactivity.
Keywords: anti-inflammatory activity, chrysin derivatives