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Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study
1 , 1 , 2 , * 1
1  University of Mons-UMONS
2  Sairem SAS

Abstract: Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200 S, Sairem's microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times.
Keywords: 1,4-DHPs; flow chemistry; Hantzsch pyridines; microwave; Raman spectroscopy; real-time monitoring