The forest complex Ouémé Supérieur–Wari Maro–Monts Kouffé in northern Benin constitutes an ecosystem of great ecological wealth but remains confronted with deforestation and accelerated degradation due to increasing anthropogenic pressures. This study aims to analyze the degradation hotspots in this complex through time and across space, highlighting human and infrastructural factors. To this end, an integrated methodological approach was mobilized, based on a diachronic analysis of multitemporal satellite images (from the years 1986 to 2024), coupled with remote sensing tools and geographic information systems (GISs). The results reveal a substantial increase in cultivated fields and fallows, from 454.12 ha (0.09% of the complex) in 1986 to 29,400.5 ha (6%) in 2024. Forest cover declined by 17.21% over the same period. Conversely, savannas expanded from 116,359.54 ha (23.73%) to 172,550.23 ha (35.19%). Land transformation processes, analyzed using Bogaert’s decision tree, show continuous agricultural expansion, with the number of patches rising from 288 in 1986 to 2,742 in 2024. However, the 2024 pattern is marked by spatial aggregation rather than new patch creation, as indicated by the increase in the average patch size from 1.6 ha to 10.7 ha. Notably, a large share of these aggregated areas is located near roads, suggesting that accessibility plays a key role in land conversion. The linear regression between the proportion of fields/fallows and proximity to asphalt roads shows a determination coefficient R² of 0.72 with a p-value < 0.01, indicating a strong and significant relationship. The fragmentation of the landscape is intensifying, particularly around asphalted roads, as well as unpaved ones. These findings highlight the need for a re-reading of protected forest management strategies, including better supervision of agricultural expansion, regulation of road developments, and increased involvement of local actors in environmental governance mechanisms.