Abstract: Cellulose, as a naturally abundant biopolymer, can be easily functionalized with various organic groups for desired purposes like applications as a biodegradable support for heterogeneous catalysis, composites matrixes and immobilization processes. Metal nanocomposites are one of the best catalysts for organic reaction beacause of their simple recoverable features. They simply can be recovered from reaction pot. A possible method simple separation and recycling of the catalysts is immobilizing catalytically active species in the surface of magnetic metal nanoparticles which can be separated from the reaction system by applying an appropriate magnetic field. In this study, we have prepared a biopolymer-based bimetallic nanocomposite via in situ synthesis of maghemite (gamma-Fe2O3) and Cu on cellulose biopolymer. It has been proven that this catalyst shows very good activities in organic synthesis. In general this nanocomposite catalyst is recoverable, green, easy separable, environmentally friendly and in the chemical reaction as a very good strategy for the synthesis of medicinal and pharmaceutical compounds compared to the traditional method.