The creation of innovative materials for accelerated wound healing based on biomimetic systems and biopolymers is an urgent task. Even knowing the rates and stages of skin wound healing, scientists face such problems as prolonged antimicrobial effects, the removal of cellular debris from the wound, the timely application of protein healing activators, and controlled bioresorption of the healing layer. In this paper, we propose an approach to solving the complex problem of accelerated wound healing using biomimetic material obtained by electrospinning followed by modification with protein molecules.

We obtained electrospun biomimetic material based on polyester of natural origin, poly-3-hudroxybutyrate (PHB), modified with hemin (Hmi) and fibrinogen (Fbg). The highly developed bioinspired structure of the material made it possible to control the rate of degradation of the polymer matrix and the release of the antimicrobial component (Hmi). Fbg as the wound healing protein activator provided accelerated wound closure by 35% on the 3rd day compared to the control (gauze and pure PHB), where the closure was 2% and 1%, respectively. At the same time, the degradation of the entire material exactly coincided in time with the rate of wound closure due to the controlled surface density. The paper presents histological studies demonstrating the high potential of the proposed materials and the developed approach. In addition, the structural, chemical, physical, and biological aspects that played a key role in successful accelerated wound closure have been investigated.