Introduction: Ethosomal gels are a novel drug delivery system that combines the benefits of gel with the unique properties of ethosomes for topical administration. Ethosomes are composed of phospholipids, nano vesicles with a high ethanol concentration (20-45%), and water, which enables them to penetrate the stratum corneum more effectively than other conventional formulations. This makes ethosomal gels an ideal platform for delivering a wide range of therapeutics, including both hydrophilic and lipophilic drugs, directly to the site of action on the skin.

Objectives: The incorporation of ethosomes into gel matrices enhances stability andcontrolled release while also providing ease of application and improved skin retention. Ethosomal gels have demonstrated great promise in the treatment of dermatological conditions such as psoriasis, fungal infections, and localized pain management.

Methods: Ethosomes were prepared using different concentrations of phospholipid PLH90, alcohol, propylene glycol, and carbopol and characterized by particle size, zeta potential, and entrapment efficiency. Furthermore, in vitro, in vivo, ex vivo, and pharmacokinetic studies were conducted.

Conclusion: The combination of ethosomal technology with gel systems can offer improved therapeutic efficacy, patient compliance, and enhanced skin bioavailability, making it a promising approach for topical drug delivery. It is advantageous to address the issue of frequent dosing caused by the shorter half-life of medications.