The decarbonization of energy-intensive separation processes is critical for achieving net-zero goals in the chemical industry. While widely used for separating azeotropic and close-boiling mixtures, pressure swing distillation (PSD) remains highly energy intensive due to significant thermal demands. This study explores the integration of electrification and hybrid heat pump-assisted systems into PSD as a pathway to enhanced sustainability. This work presents a comprehensive systems-based assessment of electrified distillation designs, with a specific focus on tetrahydrofuran–water separation as a case study.

Using Aspen Plus and Aspen Plus Dynamics for steady-state and dynamic simulations, coupled with MATLAB-based multi-criteria optimization, we evaluated key performance indicators including thermal and exergy efficiencies, CO₂ emissions reduction potential, and controllability metrics. The electrified configurations employed electric reboilers and heat pumps as partial or full substitutes for conventional steam heating.

The results show that hybrid electrified systems can reduce primary energy demand by up to 28%, while improving exergy efficiency by 22% compared to conventional setups. Dynamic controllability analysis using the Morari Resiliency Index (MRI) and Condition Number (CN) confirmed enhanced stability and responsiveness under variable electricity input scenarios. Additionally, GHG emissions were reduced by 35–45%, depending on the electricity source mix.

This study demonstrates the potential of electrification to transform PSD systems from rigid, energy-intensive operations into flexible and sustainable processes. The findings support a shift toward integrated, systems-driven design strategies in chemical separation, aligning with broader goals in process electrification, circularity, and net-zero manufacturing. This approach can serve as a blueprint for retrofitting traditional separation systems with next-generation, low-emission technologies.