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Synthesis of Pyrazole-Derived Dithioethers Using in situ Generation of Dithiolate-Ions
Published: 31 October 2014 by MDPI in The 18th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Abstract: A number of pyrazole-derived dithioethers were prepared by the reaction of diisothiuronium salts and 2-(3,5-dimethylpyrazol-1-yl)ethanol tosylate in a basic aqueous solution. Diisothiuronium salts were prepared by the reaction of thiourea with alpha,omega-dibromoalkanes containing from three to twelve methylene groups. The use of these salts allowed in situ generation of dithiolate ions, thus eliminating the need to use hazardous dimercaptanes.
Keywords: Pyrazole; thioether ligands; thiourea; thiuronium salts