Abstract: A series of some monoazaphenoxzines carboxamides evaluated against Salmonella typhi, Stapyhlococcus aureus, Escherichia coli, Klebsiella pneumonia, Streptococcus pyogene and Pseudomonas aeruginosa in a micro dilution broth assay. The results obtained showed that these compounds exhibited considerable antibacterial activity depending on the substituents on the monoazaphenoxazine ring. The best activity were obtained with substituents containing nitro-group as in 3-(-4-nitrobenzamido)-1-azaphenoxazine and chloride-group as in 3-trichloromethanamido-1-azaphenoxazine