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Optimization Process for Increasing the Yield of Crude Alkaloid from Litsea polyantha Juss. bark
* 1 , 1 , * 2 , 2 , 2
1  Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand (835215), INDIA
2  Departamento de Química Orgánica. Facultade de Ciencias. Universidade de Santiago de Compostela. 27002-Lugo. Spain

Abstract: Litsea polyantha Juss. (Lauraceae) also known as Litsea monopetala Roxb. is a small to medium sized evergreen tree distributed chiefly in tropical and subtropical Asia, Australia and the Pacific Islands. The bark of Litsea polyantha Juss. has a long history of medicinal use among the traditional healers of Oraon and Munda community of Jharkhand (India). In this work, optimization process for increasing the yield of crude alkaloid from Litsea polyantha Juss. bark was performed by taking pH and temperature as the factors influencing the yield. With the help of yield optimization by 22 factorial design the percentage yield of crude alkaloid was increased from 3.8% w/w to 17.3% w/w.
Keywords: Factorial design; Litsea polyantha; alkaloids; plant extracts; ethnopharmacology