Background:
Preliminary phytochemical analysis of the hydroalcoholic extract of Tecoma undulata (Sm.) Seem. revealed a high flavonoid content (88.66 ± 0.57 QE/g), suggesting wound-healing potential. To further elucidate its therapeutic efficacy, ointment formulations containing 5% and 10% of the extract were developed using Jathyadi Thailam as a herbal base (oil) and evaluated for wound-healing activity in Swiss albino mice.

Methods:
The wound-healing potential of the formulations was assessed using burn and excision wound models. The ointments were evaluated for their physicochemical properties, including pH, spreadability, viscosity, and stability. Parameters, including wound contraction rate, epithelialization time, collagen deposition, and tensile strength, were measured. Comparative assessments were conducted between topical and oral administration, with standard povidone-iodine ointment serving as the standard reference.

Results:
Both 5% and 10% formulations complied with standard physicochemical criteria and demonstrated significant wound-healing activity (p < 0.001) in both models compared to the control. Enhanced wound contraction, shortened epithelialization period, and increased tensile strength were observed, particularly in the burn wound model. Topical application produced superior results relative to oral administration.

Conclusion:
The hydroalcoholic extract of T. undulata, when formulated with Jathyadi Thailam, exhibits pronounced wound-healing efficacy, especially in burn wound management. These findings support its potential as a safe, natural, and effective topical therapeutic agent for treating burn injuries.