Introduction: Senile plaques (SP), composed mainly of β-amyloid (βA) peptide fibers, are a distinctive feature of Alzheimer's disease (AD). Visualizing SP using magnetic resonance imaging (MRI) poses a challenge. MRI requires specific contrast agents (CAs) to recognize SP, thereby increasing detection sensitivity. This paper describes the synthesis of two types of CAs: positive or T1 (gadolinium oxide nanoparticles (Gd₂O₃NPs) or metal complexes supported on silica nanoparticles (SiO₂NPs)) and negative or T2 (iron oxide nanoparticles (IONPs). These CAs are functionalized with Amilovys compounds as target ligands (TLs) related to βA in order to design smart probes for the specific diagnosis of AD using MRI. Method: Gd₂O₃NPs, SiO₂NPs and IONPs were obtained by polyol solvothermal, sol-gel and thermal decomposition methods, respectively. For Gd₂O₃NPs some experimental conditions were optimized (molar ratio of precursors, solvent, and reaction time). After the functionalization with carboxyl or amino terminal groups, Amylovis compound was grafted to the SiO₂NPs and IONPs using carbodiimidation reaction. The grafting percentage was indirectly determined by means of the quantification of free Amylovis (HPLC). Results: Optimal conditions for the synthesis of Gd₂O₃NPs were 1:3 as precursor molar ratio, ethylenglicol as solvent and 4 h at 180 ˚C. All NPs were characterized using FT-IR (evidenced the metal-oxygen bonds and ligands at the surface of NPs), microscopic (TEM sizes of Gd₂O₃: 28 nm; SiO₂: 128 nm; IONPs: 12 nm), and granulometric techniques. For IONPs, the grafting efficiency (30-100 %) do not impact on the colloidal stability and relaxivity properties of the so-functionalized NPs. Conclusion: Three dispersions of Amylovis-functionalized metal nanoparticles (Gd₂O₃, metal-complexed SiO₂, and IONPs) were successfully synthesized. Their surface functionalization and nanometric sizes (all under 200 nm) were confirmed. This work successfully lays the groundwork for developing targeted MRI contrast agents to improve the detection of senile plaques in Alzheimer's disease.