Clitoria ternatea L. (CT) is a perennial herbaceous plant with deep blue flowers native to tropical Asia. Present study aims at characterization of phytochemicals from crude methanolic extract of CT flower and evaluation of antidiabetic and antidepressant effects on 15% fructose induced diabetic mice. GC-MS was employed for identification of chemical constituents from CT flower. Molecular docking and in-silico ADMET analysis were performed to validate the results. Thirty-one phytochemicals were identified. In diabetic mice, metformin reduced glucose from 13.82±0.69 to 11.46±1.03 mmol/L after 1 week and 7.68±0.40 mmol/L after 2 weeks. CT extract at 200 and 400 mg lowered glucose to <10 and <6.8 mmol/L after the 1^st and 2^nd week, respectively. In behavioral test, within 5 minutes, average head-dipping increased from 5.7±1.21 to 11.5±1.64 and for metformin, while it increased to 11.5±1.64 and 13.8±1.83 for 200 mg and 400 mg after 1^st week. All three groups reached ~21 dippings after 2^nd week. In Tail Suspension Test (TST), immobility time 20.9±1.59 decreased to 13.6±1.12 seconds, 14.8±1.45 seconds, and 8.3±0.59 seconds after 1^st week, and to 8.1±1.15 seconds, 8.6±0.79 seconds, and 6.8±1.01 seconds after 2^nd week for metformin, 200 mg and 400 mg, respectively. In Elevated Maze Test (EMT), diabetic mice exhibited 5.8±1.33 exploratory movements within 5 minutes, increasing to 14±1.26, 15±1.26, and 19.3±1.86 after 1 week, and 14.5±0.55, 19.5±2.07, and 23.5±2.26 after 2 weeks for metformin, 200 mg and 400 mg, respectively. Molecular docking studies against five anti-diabetic and five anti-depressant targets further validated the findings, and Stigmasterol and γ-Sitosterol exhibited best results (-7.0 to -10.5 kcal/mol) which also complied with good ADMET profile. Our study connects the outcomes of in-vivo and in-vitro anti-diabetic and anti-depressant activities to the molecular mechanisms involved in treating diabetes and depression by the drug-like constituents present in CT flower.