It is known that thioamides containing hydrogen atoms in the α-position of the thiocarbamoyl group exhibit a CH-acidic character. This property is widely used to produce various heterocycles (in particular, nicotinamide derivatives) through reactions of such thioamides with 1,3-dielectrophiles. Nicotinamides are present in living systems, and as medicines can be used to treat a wide range of diseases.The purpose of the work: synthesis of new nicotinamide derivatives based on monothiomalondianilide and investigation of their properties. According to the known method, we synthesized the initial monothiomalondianilide starting from phenyl isothiocyanate and acetylacetone. The structure of monothiomalondianilide is confirmed by spectral data, as well as X-ray results. Next , the reaction of monothiomalondianilide with arylidenemalonitriles, available by the Knoevenagel reaction, or with aromatic aldehydes and malonitrile in the presence of a base (multicomponent approach) leads to the formation of cyclic Michael adducts - nicotinamide derivatives. New compounds have been studied spectrally (FTIR, NMR 1H, 13C), the structure is confirmed by X-ray diffraction data. In the future, it is planned to expand the library of products, as well as study their properties. According to the results of molecular docking using the GalaxyWeb Sagittarius protocol, one of the products has affinity (ΔG = -22.586 kcal/mmol) to the protein complex H-Ras:SOS (PDB ID 6pf6, UniprotIDP04818), which indicates the potential prospects of studying the antitumor properties of the compound.