Introduction:
Fused nitrogen-containing heterocycles such as naphthyridines are privileged structural motifs found in a range of biologically active molecules and functional materials.^[1–3] Their unique electronic and structural features make them attractive scaffolds in drug discovery, fluorescence-based sensing, and optoelectronic applications.^[4,5] However, existing synthetic methods for these frameworks often involve multi-step procedures, harsh conditions, and limited control over stereoselectivity.^[6]

Methods:
In this work, we present a one-pot, silver-catalyzed method for the highly diastereoselective synthesis of fused polycyclic 1,7-naphthyridine derivatives. The reaction proceeds under mild conditions and tolerates a wide array of functional groups, allowing the incorporation of diverse substituents. The protocol is scalable to gram quantities and requires only celite filtration, evaporation, and column chromatography, eliminating the need for extensive purification.

Results:
This efficient and operationally straightforward method delivers products in good to excellent yields with high diastereoselectivity. The broad substrate scope and mild conditions showcase the robustness of the transformation. Structural confirmation and stereochemical outcomes were supported by NMR analysis and, in select cases, by single-crystal X-ray diffraction.

Conclusion:
This study expands the synthetic utility of silver catalysis in complex heterocycle construction. The resulting 1,7-naphthyridine derivatives are being further investigated for their photophysical properties with potential applications in light-emitting devices and solar energy materials. Simultaneously, their biological activity is being evaluated to identify leads of therapeutic relevance. Overall, this method provides a versatile platform for accessing functional heterocyclic frameworks relevant to materials science and medicinal chemistry.