Abstract: A trans-disciplinary frame is proposed, aimed at addressing the very understanding of information in all its variety. It aims at unifying perspectives and integrating techniques from different fields of knowledge and practice, searching for the most overarching account of information phenomena, a better formalization of real processes and a global stance towards problems concerning information. Such research frame might try to answer: Which are the basic distinct accounts of information to be applied in fields from telecommunication to philosophy, from biology to documentation, from logic to quantum physics? Which are the minimum primitive concepts that may cover all of them? Is a unified theory feasible? Could a better information measure be found? Could the societal and practical interest be better preserved in an integrated perspective of information? The methodological proposal aims at opening a space for the interweaving of different scientific frameworks (characterized by specific paradigms and methodologies) to delve into the very landscape of information, searching for a transdisciplinary treatment of theoretical, technical and practical problems concerning information. It is based on an already active interdisciplinary International community and a critical mass of research groups at the global level. By means of bridging these communities, a new transdisciplinary science of information might emerge as an integrated framework in which information will be considered in all its formal, natural, cognitive, social, technical, ethical and philosophical aspects.