Introduction:
Caffeine is a common ergogenic aid in both power and endurance sports, yet its performance effects vary widely among individuals, largely due to genetic differences. CYP1A2 and ADORA2A influence caffeine metabolism rate and central nervous system responsiveness, while ACTN3, AMPD1, ADRB2, AGTR2, HFE, and NOS3 affect power and endurance capacities. This case report evaluates an athlete’s caffeine-related genetic profile alongside their power and endurance potential to develop personalized nutrition and training recommendations.

Methods:
An anonymized genetic panel from a male athlete, obtained through an Epigenetic Coaching test, was analyzed. The participant provided informed consent for the anonymized use of his data in research. Genotypes related to caffeine metabolism (CYP1A2, ADORA2A), power (ACTN3, AMPD1, ADRB2), and endurance (AGTR2, HFE, NOS3) were assessed and compared with performance-related polymorphisms in the literature to create individualized strategies.

Results:
The athlete showed intermediate caffeine metabolism (CYP1A2 AC) and low performance-enhancement response (ADORA2A CC), suggesting limited ergogenic benefit and possible adverse effects with high caffeine intake. Power genotypes ACTN3 CT and AMPD1 CC indicated moderate fast-twitch fiber activity and anaerobic capacity, while ADRB2 GG supported explosive power potential. Endurance genotypes AGTR2 CC and HFE CG were linked to advantages in oxygen transport and aerobic efficiency, though NOS3 CT limited elite-level endurance potential. The recommended plan included high-intensity strength training 2–3 times per week, moderate-intensity endurance training 3–4 times per week, and limiting caffeine intake to <3 mg/kg at least two hours pre-exercise.

Conclusion:
Assessing caffeine-related genetic variants alongside power and endurance profiles is useful for determining optimal ergogenic support and training strategies. A nutrigenetic-based personalized approach can enhance performance while minimizing adverse effects.