Metal–organic frameworks (MOFs) are a class of porous and highly ordered crystalline materials composed of metal ions or clusters coordinated with organic linkers. MOFs possess a high surface area, porosity, chemical and thermal stability, and the ability to be tailored using both organic and inorganic units. MOFs also exhibit antibacterial, biodegradable, and biocompatible properties depending on the metal and organic linker used. Due to these properties of MOFs, they are utilized in a wide range of applications, such as the storage of energy-related gases like hydrogen, the adsorption of chemicals, the detection of different molecules, the delivery of drugs, etc. Because of their high drug-loading capacity and slow-release processes, the drug delivery properties of MOFs are very crucial in biomedicine. Additionally, the physicochemical and mechanical properties of MOFs may also help improve the quality of the desired materials. Despite their extensive biomedical applications of MOFs, their potential in dentistry remains largely unexplored. In fact, MOFs are particularly relevant for dental research. For example, MOFs could be very useful in preparing dental composites or coatings for implants. The organic linkers of MOFs can be modified to introduce specific groups, such as methacrylate, which is useful for dental composites. Antibacterial coatings for implants are also possible. Herein, I aim to introduce the potential of MOFs to the field of dental research. This presentation will address detailed information about the synthesis, characterization, and application areas of MOFs, and then explore the application of MOFs as emerging, innovative materials in dental research. Consequently, this overview highlights both the opportunities and challenges of employing MOFs in restorative and implant dentistry, pointing towards future directions for research and clinical translation.