Neurorehabilitation is undergoing a digital transformation, with telerehabilitation emerging as a critical tool for ensuring continuity of care. This systematic review aims to evaluate the efficacy of remote rehabilitation interventions compared to conventional in-clinic therapies in improving motor functions and quality of life for patients with neurological conditions, such as stroke and multiple sclerosis. A systematic search was conducted across PubMed, Scopus, and Web of Science for randomized controlled trials (RCTs) published between 2020 and 2025. The inclusion criteria focused on adult populations undergoing digital or remote neurorehabilitation interventions, utilizing outcomes such as the Fugl-Meyer Assessment (FMA), Berg Balance Scale (BBS), and various Quality of Life (QoL) metrics. Preliminary analysis of the selected studies indicates that telerehabilitation is at least as effective as face-to-face therapy in promoting neuroplasticity and motor recovery. Key findings suggest that digital platforms enhance patient adherence due to the convenience of home-based training. Furthermore, interventions incorporating biofeedback and synchronous monitoring showed significantly higher improvements in functional independence compared to non-monitored home exercises. Telerehabilitation represents a viable and evidence-based alternative to traditional methods, addressing geographical and mobility barriers. However, the heterogeneity of digital platforms and the need for standardized protocols remain challenges. This review highlights the potential of integrating telemedicine into routine clinical practice to optimize functional outcomes and long-term disability management.