A variety of quinazolinones are readily prepared via one-pot three-component reaction in good to excellent yields. The desired products were obtained from the reaction of dimedone, various aldehydes with 2-aminobenzimidazole under mild reaction conditions using MCM- 41-SO3H as effective catalyst in green and reusable catalyst in refluxing ethanol has been developed. Starting from the corresponding available materials, this friendly and environmentally free-metal procedure has been successfully extended to the synthesis of benzimidazoquinazolinones. The salient advantages of this method are mild reaction conditions, nontoxic and inexpensive catalyst, environmentally benign, high to excellent yields, shorter reaction times, easy operation, and no column chromatographic separation.[1,2]

[1] M. Heravi, F. Derikvand, L. Ranjbar, “Sulfamic acid–catalyzed, threeComponent, one-pot synthesis of [1, 2, 4] triazolo/benzimidazolo quinazolinone derivatives”, synthetic communications, 2010, 677–685.

[2] Gh. H. Mahdavinia, M. M. Ghanbari, H. Sepehrian, F. Kooti, “MCM-41 functionalized sulfonic acid catalyzed one-pot synthesis of 1,8-dioxo-octahydroxanthenes”, 2010, 117-120.