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Synthesis and Structural Characterization of 1,4-Diazepines Related to Curcumin
1 , * 1 , 1 , 2
1  Departamento de Química Orgánica y Bio-Orgánica, Facultad de Ciencias, UNED
2  Instituto de Química Médica, Centro de Química Orgánica Manuel Lora-Tamayo, CSIC


The reactivity of (E)-5-(4-hydroxy-3-methoxyphenyl)-1-phenylpent-4-ene-1,3-dione with ethylenediamine has been studied in different experimental conditions. Two dihydro-1,4-diazepines have been obtained and fully characterized by 1D and 2D multinuclear NMR spectroscopy and HRMS.

Keywords: 1,4-diazepines, curcumin, 1H, 13C, 15N NMR
Comments on this paper
Sunil Gaikwad
Organic chemistry
why you have not taken single crystal of both Compounds 3 and Compound 4.
This is very interesting work simple and easy workout in the simple laboratory.
Have you chick their biological activity?
good work.
Dionisia Sanz
Unfortunately for the moment we have no crystals suitable for X-ray structure.
Yet we have not made any biological tests, but we intend to do them