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SYNTHESIS OF 1, 3 – DIKETOKETONES A NOVEL ANTIMICROBIAL AND ANTI FUNGAL AGENTS
Published: 30 October 2015 by MDPI in The 19th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
An improved method for synthesis of 2,4-diacetyl-cyclohexanone derivatives is reported with enhanced yield in presence of DMSO as solvent. In situ, reaction of aromatic and hetero aromatic aldehydes with β-oxo-ketones undergoing Knoevenagel condensation, Michael addition followed by aldol condensation to give the desired product in excellent yield. displayed prominent mild to moderate antimicrobial and antifungal activities. The 2,4-diacetyl-cyclohexanone derivatives thus obtained have been characterized by 1H NMR, 13CNMR, FT-IR, MASS, HRMS and X-ray single Crystallography spectroscopic methods.
Keywords: Antimicrobial activity, Heteroaromatic aldehyde, β-keto ketones, DMSO, Knoevenagel /Michael/Aldol reaction.1HNMR, 13C NMR, X-ray single crystallography.
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