Africa's rapid demographic transformation characterized by a youthful population, accelerated urbanization, and expanding metropolitan regions—has intensified pressures on urban mobility and transportation systems. This study examines how these demographic shifts contribute to growing spatial mismatch in the African cities of Accra, Lagos, and Nairobi. These cities face increasing strain on transport systems, infrastructure, and spatial planning, resulting in significant inequalities in access to opportunities.Drawing on spatial mismatch theory and mobility justice frameworks, the study explores how the geographical separation between residential areas and employment centers, combined with weak and fragmented transport systems, deepens socio-economic exclusion. Through document analysis of World Bank and UN-Habitat reports, household travel surveys, and related reports, the study adopts a comparative case study approach to identify patterns in transport systems such as trotro, matatu, and danfo. While these systems play a central role in urban mobility, they remain unreliable and poorly integrated into formal urban planning structures.The study concludes that achieving inclusive urban development requires a shift toward integrated, equitable, and sustainable transport policies, alongside investments in mass transit that prioritize vulnerable populations and support rapidly growing urban populations. It further contributes to urban theory by extending spatial mismatch to global contexts, demonstrating that mobility inequality is central to understanding urban governance, labor market access, and inclusive development in rapidly urbanizing African cities.