Climate change constitutes one of the most critical challenges for contemporary cities, directly affecting urban functionality, sustainability, and quality of life. Under these conditions, enhancing urban resilience and adaptability becomes imperative, requiring urban design to adopt innovative, nature-inspired strategies. This study approaches biomimetic design as a comprehensive method for addressing the impacts of climate change on the built environment. The research investigates mechanisms and strategies observed in natural systems that exhibit resilient, adaptive behavior under changing climatic conditions. These mechanisms are analyzed and translated into principles of urban design and spatial organization, aiming to support the development of urban environments that perform efficiently in environmental and climatic terms. The findings indicate that the application of biomimetic strategies within the urban context can be particularly effective in responding to climate-induced pressures. As an indicative example, the study examines the urban heat island phenomenon, one of the most evident impacts of climate change in cities. Through the adoption of biomimetic design approaches, this phenomenon can be significantly mitigated or even eliminated by reconfiguring urban systems in alignment with natural adaptive processes. In conclusion, biomimetic design is proposed as a suitable and forward-looking strategy for strengthening urban resilience and adaptability. Rather than addressing isolated climatic phenomena, it offers an integrated framework that contributes to the overall environmental robustness of urban systems, supporting cities in their long-term response to climate change.