Introduction: Breast cancer (BC) survivors often experience various medically unexplained symptoms after surgery, including fatigue, pain, and psychological distress, which can negatively affect patients’ quality of life (QoL). These have led to a growing interest in integrative therapies to manage psychosomatic symptoms with mind–body interventions. The aim of this pilot study is to evaluate the effects of Qigong mind–body intervention on symptoms and QoL in post-surgical BC survivors.

Methods: This single-arm pilot study was conducted at the AMICO Clinic (IRCCS-CROB, Southern Italy), where fourteen women (aged 42–73 years; stage I–III BC) were enrolled. Participants attended weekly 60-minute supervised Qigong sessions for 8 weeks and were instructed to engage in home practice with a minimum target of 2–3 hours/week. Outcomes were assessed at baseline and post-intervention using the Edmonton Symptom Assessment System and the 12-Item Short Form Health Survey. Post-intervention qualitative exit interviews were conducted to explore participants’ experiences and perceived benefits.

Results: The Qigong intervention was well tolerated, with improvements observed across both physical and psychological domains. Participants demonstrated reductions in pain (-28%), fatigue (-28%), anxiety (-43%), mood disturbances (-28%), sleep disturbances (-22%), and melancholy (-22%). Hot flashes decreased by 7%, with greater reductions noted among younger participants, especially when combined with light aerobic activity. Qualitative findings were like quantitative outcomes, with participants reporting improvements in overall well-being, enhanced emotional regulation, increased body awareness, strengthened social connectedness, and greater engagement in self-care.

Conclusions: This pilot study suggests Qigong is a feasible and acceptable intervention for the management of symptoms in BC survivors. Delivered in a public integrative oncology setting, the proposed mind–body practices demonstrate the applicability of Qigong in a real-world clinical context of BC care.