Background: A diagnosis of cancer is associated with an elevated risk of arterial thrombotic events (ATEs), including myocardial infarction (MI) and ischemic stroke. This systematic review synthesizes the current evidence on the epidemiology, risk factors, time-dependent risks, and outcomes of ATEs across a spectrum of malignancies to guide clinical practice and future research.

Methods: We systematically searched PubMed and Science Direct from inception to December 2025 for studies reporting on ATEs in cancer patients. Data on patient demographics, cancer types, treatment modalities, ATE outcomes, and risk estimates were extracted. The risk of bias was assessed using appropriate tools.

Results: We included 43 studies. The evidence demonstrates a clear association between cancer and an increased risk of ATEs (HR/OR range: 1.5-3.0). High-risk malignancies included lung, pancreatic, gastrointestinal, and brain cancers. The risk was most pronounced in the peri-diagnostic period and first 6–12 months after diagnosis. Key contributing factors included advanced cancer stage, specific chemotherapies (e.g., platinum-based agents), radiotherapy, and the perioperative period. Traditional cardiovascular risk factors compounded this risk. Despite the established link, evidence for optimal prophylactic strategies is lacking.

Conclusion: Cancer confers a significant and time-dependent increased risk of ATEs, necessitating increased clinical vigilance. A proactive, multidisciplinary approach involving cardio-oncology is essential for risk stratification, aggressive management of traditional risk factors, and patient education. Future research must focus on mechanistic studies, predictive biomarker development, and randomized controlled trials to establish effective prevention and treatment strategies.