In the European chemical industry, there is a strong drive to shift from fossil to renewable resources in the pursuit of sustainability. Sophorolipids, a class of biosurfactants, are interesting renewable resources, since they combine a complex structure with divergent biological and physico-chemical properties. The microbially produced lactonic sophorolipids were used for the production of a broad range of innovative sophorolipid amines 1 and sophorolipid quaternary ammonium salts 2. These sophorolipid quaternary ammonium salts were evaluated for their antimicrobial activity against Gram-negative and Gram-positive bacterial test strains. Minimum inhibitory concentration (MIC) values were determined for the active compounds. Values of 5-8 µM results were obtained for the derivatives containing an octadecyl chain attached to the nitrogen atom, compared to values of 10-52 µM for the antibiotic gentamicin sulfate. These results shows great promise for modified sophorolipids in the medical sector, for example for the inhibition of biofilm formation.
Previous Article in event
Next Article in event
Quaternary Ammonium Sophorolipids as Renewable Based Antimicrobial Products
Published: 10 November 2015 by MDPI in 1st International Electronic Conference on Medicinal Chemistry session ECMC-1