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Quaternary Ammonium Sophorolipids as Renewable Based Antimicrobial Products
1 , 1 , 2, 3 , 2 , 4 , 4 , * 1
1  SynBioC, Department of Sustainable Organic Chemistry and Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
2  InBio, Department of Biochemical and Microbial Technology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.
3  Bio Base Europe Pilot Plant (BBEU), Rodenhuizekaai 1, 9042 Ghent (Desteldonk), Belgium
4  LCT, Department of Chemical Engineering and Technical Chemistry, Ghent University, Technologiepark 914, 9052 Ghent, Belgium

Published: 10 November 2015 by MDPI in 1st International Electronic Conference on Medicinal Chemistry session ECMC-1

In the European chemical industry, there is a strong drive to shift from fossil to renewable resources in the pursuit of sustainability. Sophorolipids, a class of biosurfactants, are interesting renewable resources, since they combine a complex structure with divergent biological and physico-chemical properties. The microbially produced lactonic sophorolipids were used for the production of a broad range of innovative sophorolipid amines 1 and sophorolipid quaternary ammonium salts 2. These sophorolipid quaternary ammonium salts were evaluated for their antimicrobial activity against Gram-negative and Gram-positive bacterial test strains. Minimum inhibitory concentration (MIC) values were determined for the active compounds. Values of 5-8 µM results were obtained for the derivatives containing an octadecyl chain attached to the nitrogen atom, compared to values of 10-52 µM for the antibiotic gentamicin sulfate. These results shows great promise for modified sophorolipids in the medical sector, for example for the inhibition of biofilm formation.