The increasing prevalence of implants is parallel to the global aging population. Titanium alloy Ti-6Al-4V (Ti 64) is widely utilized in biomedical applications; however, concerns regarding aluminium (Al) and vanadium (V) ion release and their potential long-term effects on human health are prompting the exploration of alternative materials. Among these, β-titanium alloys that are free of Al and V are being investigated. Ti 21S, a metastable β-titanium alloy, demonstrates a lower Young’s modulus that aligns more closely with the mechanical properties of human cortical bone, thereby mitigating the issue of stress shielding. In this study, Ti 64 and Ti 21S were fabricated using laser powder directed energy deposition (LP-DED), and their properties, including density, microstructure, hardness, and corrosion behaviour in a 0.9% NaCl solution, were assessed. Optimized LP-DED parameters for Ti 21S yielded over 99.9% of theoretical density, a fully β microstructure, uniform hardness, and stable passivation with low corrosion currents, indicating strong resistance to corrosive degradation. These findings confirm that Directed Energy Deposition can successfully produce high-quality Ti 21S while maintaining its advantageous properties. Overall, Ti 21S exhibits corrosion performance at least comparable to that of Ti 64 while offering a mechanical response characterized by a lower modulus closer to that of bone. In light of the increasing demand for durable implants in an aging population, Ti 21S presents a promising alternative to Ti 64 for future biomedical applications.