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Conception, synthesis, characterization and antimicrobial evaluation of new ferrocene-based derivatives inspired by the bisacodyl lead structure
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Published:
04 December 2015
by MDPI
in MOL2NET'15, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 1st ed.
congress CHEMBIO.MOL-01: Org. Chem., Med. Chem., Pharm. Industry, & Mol. Biol., Congress, Paris, France-Galveston, USA, 2023., Rostock, Germany-Bilbao, Spain-Galveston, Texas, USA, 2015
Abstract:
The antibacterial activity of bisacodyl, a drug used in therapeutic as laxative, and its ferrocenyl analogues was investigated against Gram-positive and Gram-negative foodborne pathogens including Listeria monocytogenes, Escherichia coli, Enterococcus faecalis, Salmonella enterica, Micrococcus luteus and Staphylococcus aureus. The results showed that most of these compounds exhibit an excellent antimicrobial activity, and the bisacodyl analogues seemed to be more bactericides than bacteriostatic.
Keywords: bisacodyl; ferrocene; antibacterial activity
