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Conception, synthesis, characterization and antimicrobial evaluation of new ferrocene-based derivatives inspired by the bisacodyl lead structure
1 , * 1 , 2 , 2 , 1
1  Equipe de Chimie Moléculaire du Laboratoire CMGPCE, EA 7341, Conservatoire national des arts et métiers, 2 rue Conté,75003, Paris
2  Centre de Biotechnologie de Sfax, Université de Sfax, Route de Sidi Mansour Km 6, BP 1177, 3018 Sfax, Tunisia


The antibacterial activity of bisacodyl, a drug used in therapeutic as laxative, and its ferrocenyl analogues was investigated against Gram-positive and Gram-negative foodborne pathogens including Listeria monocytogenes, Escherichia coli, Enterococcus faecalis, Salmonella enterica, Micrococcus luteus and Staphylococcus aureus. The results showed that most of these compounds exhibit an excellent antimicrobial activity, and the bisacodyl analogues seemed to be more bactericides than bacteriostatic.

Keywords: bisacodyl; ferrocene; antibacterial activity