Please login first
Synthesis of triazoloquinazolinone derivatives employing Silica-based sulfonic acid (MCM- 41-SO3H): A mild, reusable and highly efficient heterogeneous catalyst
* , ,
1  Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IRAN.


A multicomponent reaction (MCR) can create highly complex molecules from readily available starting materials without the complicated purification operations; thus, MCRs are resource and time-effective and economically favorable processes in diversity generation1. A wide variety of quinazolinone derivatives have been synthesized by condensation of 3-amino- 1, 2, 4-triazole as amine sources, with dimedone and aromatic aldehydes in the presence of 20 mol % of MCM-41-SO3H as effective catalyst in green and reusable catalyst in refluxing DMF conditions through one-pot reactions. Triazoloquinazolinone are important because of their wide range of biological activities, application in medicinal chemistry, pharmaceutical industry and agrochemicals as herbicides and active pharmaceuticals2.

1. D. J. Ramon, M. Yus, Angew. Chem. 2005, 44, 1602.
2. V. Haridas, K. Lal, Y. K. Sharma. Tetrahedron Lett. 2007, 48, 4719.

Keywords: triazoloquinazolinone derivatives ,MCM- 41-SO3H, heterogeneous catalyst