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Synthesis, plant growth regulating activity and herbicide antidote activity of new pyrano[2,3-d]pyrimidines
* 1, 2, 3 , 1 , 1 , 1, 4 , 4 , 5
1  Kuban State University, 149 Stavropolskaya Str., Krasnodar 350040, Russian Federation
2  ChemEx Lab, Vladimir Dal’ Lugansk National University, Lugansk, 91034 Russia.
3  North-Caucasus Federal University, 1 Pushkina St., 355009 Stavropol, Russian Federation
4  All-Russian Research Institute of Biological Plant Protection, Laboratory of plant growth regulators, 350039 Krasnodar, Russian Federation
5  Kuban State Technological University, 2 Moskovskaya st., 350072 Krasnodar, Russian Federation


The reaction of S-alkyl thiobarbiturates with aromatic aldehydes and malononitrile (or arylmethylidenemalononitrile) leads to hitherto unknown 4Н-pyrano[2,3-d]pyrimidines. Plant growth regulating activity and herbicide antidote activity were studied in the series of the obtained compounds. We found that ethyl {[7-amino-6-cyano-5-(4-methoxyphenyl)-4-oxo-3,5-dihydro-4Н-pyrano[2,3-d]pyrimidin-2-yl)thio}acetic acid revealed moderate activity as 2,4-D antidote.

Keywords: S-alkyl thiobarbiturates, 4Н-pyrano[2,3-d]pyrimidines, NMR studies, plant growth regulating activity, herbicide antidote activity