Synthesis, plant growth regulating activity and herbicide antidote activity of new pyrano[2,3-d]pyrimidines

¹ Kuban State University, 149 Stavropolskaya Str., Krasnodar 350040, Russian Federation
² ChemEx Lab, Vladimir Dal’ Lugansk National University, Lugansk, 91034 Russia.
³ North-Caucasus Federal University, 1 Pushkina St., 355009 Stavropol, Russian Federation
⁴ All-Russian Research Institute of Biological Plant Protection, Laboratory of plant growth regulators, 350039 Krasnodar, Russian Federation
⁵ Kuban State Technological University, 2 Moskovskaya st., 350072 Krasnodar, Russian Federation

Published: 01 November 2016 by MDPI in The 20th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-20-a048

Abstract:

The reaction of S-alkyl thiobarbiturates with aromatic aldehydes and malononitrile (or arylmethylidenemalononitrile) leads to hitherto unknown 4Н-pyrano[2,3-d]pyrimidines. Plant growth regulating activity and herbicide antidote activity were studied in the series of the obtained compounds. We found that ethyl {[7-amino-6-cyano-5-(4-methoxyphenyl)-4-oxo-3,5-dihydro-4Н-pyrano[2,3-d]pyrimidin-2-yl)thio}acetic acid revealed moderate activity as 2,4-D antidote.

Keywords: S-alkyl thiobarbiturates, 4Н-pyrano[2,3-d]pyrimidines, NMR studies, plant growth regulating activity, herbicide antidote activity

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