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Preliminary Study of Photosynthesis-Inhibiting Activity of Substituted Phenylcarbamoylphenyl N-alkylcarbamates
Published: 22 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry
Abstract: In this study, a series of nine 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl N-alkylcarbamates was prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. For the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).
Keywords: 4-Chloro-2-(3,4-dichlorophenylcarbamoyl)-phenyl N-alkylcarbamates; Lipophilicity; PET inhibition; Spinach chloroplasts; Structure-activity relationships