Synthesis of 20-N-Methylpurpuramine E, an Antitubercural Metabolite from Pseudoceratina sponge

Paul Groundwater; Mark Gray; Sanjib Bhakt; Juan Guzman; J. Jonathan Harburn; Suresh Kottakot

doi:10.3390/ecsoc-14-00430

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Synthesis of 20-N-Methylpurpuramine E, an Antitubercural Metabolite from Pseudoceratina sponge

Paul W. Groundwater

¹,

Mark Gray

²,

Sanjib Bhakt

³,

Juan David Guzman

³,

J. Jonathan Harburn

^{*

2},

Suresh K. Kottakot

¹ Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
² Sunderland Pharmacy School, University of Sunderland, Wharncliffe Street, Sunderland, SR1 3SD, UK
³ Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, Bloomsbury London, WC1E 7HX, UK

Published: 31 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry

https://doi.org/10.3390/ecsoc-14-00430

Abstract: 0-N-Methylpurpuramine E has been successfully synthesized in 2 steps in good yield from readily available starting materials. Structural elucidation has been confirmed through direct comparison with spectroscopic data of isolated natural product.20-N-Methylpurpuramine E has been shown to have MIC = 5 μg mL^-1 against Mycobacterium bovis.

Keywords: marine sponge metabolites, bromotyramine, bromotyrosine, antituberclar

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Paul Groundwater

Mark Gray

Sanjib Bhakt

Juan Guzman

J. Jonathan Harburn

Suresh Kottakot