The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy. We report here, that inclusion of monocyclic terpenoid esters in phospholipid liposomes leads to growth of excimer to monomer ratio (IE/IM) indicating a decrease of membrane microviscosity. Another mechanism of influence on biomembranes was proposed for ester of bicyclic borneol ‒ in this case a high ratio of vibronic peak intensities (I1/I3) was revealed. The addition of terpenoid esters appears in the FT-IR spectra as intensity reduction of absorption bands associated with C=O, P=O and Р‒О‒С groups of lecithin phospholipids. Similar results were obtained after esters addition to lipids isolated from stratum corneum indicating a decrease of hydrogen bonds number between polar groups of lipids.
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The Effect of Terpenoid Esters on Membrane Structure Investigated by Fluorescence and Fourier-transform Infrared Spectroscopy
Published:
01 November 2017
by MDPI
in 3rd International Electronic Conference on Medicinal Chemistry
session ECMC-3
Abstract:
Keywords: terpenoids, esters, fluorescence probe, FT-IR spectroscopy, liposomes, stratum corneum
Comments on this paper
George Sladkovsky
9 November 2017
Great paper
Very interesting and comprehensive study!
Alex Lypovets
9 November 2017
In depth approach
The amount of work and attention to details in this paper is very impressive!
Dorothy Robbins
30 November 2017
Nice work!
Nice work! I like your study and analysis.
Natalie Lozitsky
1 December 2017
Great research
Very comprehensive study. Good job!
Vernon Nellis
1 December 2017
Oh how we love our illustrstions
The data is interesting as is the paper. it will be very interesting to see how this research translates to human subjects. Nice paper.