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The Effect of Terpenoid Esters on Membrane Structure Investigated by Fluorescence and Fourier-transform Infrared Spectroscopy
Mariia Nesterkina * 1 , Sergii Smola 2 , Iryna Kravchenko 1, 3
1  Department of Organic and Pharmaceutical Technologies, Odessa National Polytechnic University
2  A.V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine
3  Department of Pharmaceutical Chemistry, I.I. Mechnikov Odessa National University

Published: 01 November 2017 by MDPI in 3rd International Electronic Conference on Medicinal Chemistry session ECMC-3
10.3390/ecmc-3-04646
Abstract:

The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy. We report here, that inclusion of monocyclic terpenoid esters in phospholipid liposomes leads to growth of excimer to monomer ratio (IE/IM) indicating a decrease of membrane microviscosity. Another mechanism of influence on biomembranes was proposed for ester of bicyclic borneol ‒ in this case a high ratio of vibronic peak intensities (I1/I3) was revealed. The addition of terpenoid esters appears in the FT-IR spectra as intensity reduction of absorption bands associated with C=O, P=O and Р‒О‒С groups of lecithin phospholipids. Similar results were obtained after esters addition to lipids isolated from stratum corneum indicating a decrease of hydrogen bonds number between polar groups of lipids.

Keywords: terpenoids, esters, fluorescence probe, FT-IR spectroscopy, liposomes, stratum corneum
Comments on this paper
George Sladkovsky
Great paper
Very interesting and comprehensive study!

Alex Lypovets
In depth approach
The amount of work and attention to details in this paper is very impressive!

Dorothy Robbins
Nice work!
Nice work! I like your study and analysis.

Natalie Lozitsky
Great research
Very comprehensive study. Good job!

Vernon Nellis
Oh how we love our illustrstions
The data is interesting as is the paper. it will be very interesting to see how this research translates to human subjects. Nice paper.


 
 
 
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