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Synthesis of Luminescent Squaramide Monoesters: Cytotoxicity and Cell Imaging Studies in HeLa Cells
Published: 01 November 2017 by MDPI in 3rd International Electronic Conference on Medicinal Chemistry session ECMC-3

Novel luminescent squaramide monoesters functionalised with different fluorophore groups have been synthesized and explored in cell imaging for the first time.

Cytotoxicity studies performed in HeLa cervical cancer cells revealed high activity for some of these novel structures, highlighting the importance of the fluorescent fragment in the efficiency of these promising anticancer agents.

In addition, fluorescence cell microscopy disclosed the different biodistribution behaviour depending on the fluorescent moiety, and the possibility of nuclear localisation of chiral non planar squaramide monoesters.

Keywords: squaramide, luminescence, cancer, HeLa
Comments on this paper
Andrea Porcheddu
great project!!
Hi Raquel and M.Concepción,

your idea is really interesting. The process is solvent-sensitive, I'm wrong? Did you try to carry out the synthesis of squaramides 1-8 in water (physiological medium)? and neat? what are limits and/or problems of this synthetic process?