Prostatitis describes a combination of infectious diseases (acute and chronic bacterial prostatitis), chronic pelvic pain syndrome (CPPS) or asymptomatic prostatitis Most men with “chronic prostatitis” have chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), characterized by pelvic pain. The etiology of this syndrome is not fully known, the evaluation has been controversial and treatment is, unfortunately, frequently unsuccessful. Focused multimodal therapy appears to be more successful than empiric monotherapy. In that sense, it is important to know how nanoparticles will function in an animal model. The present paper reviews promising methods to capture prostate targeting.