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The Reactions of Mitomycin C with Dithiols I. Reductive Activation
Published: 31 October 2010 by MDPI in The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry
Abstract: We report that the clinically used antitumor drug mitomycin C is reductively activated in vitro by simple thiols; a mechanism for this activation is proposed based on kinetic data and the identification of mitosene metabolites. The biological implications of these findings are discussed.