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The Reactions of Mitomycin C with Dithiols I. Reductive Activation
1  Departmento de Química Orgánica, Universidade de Santiago de Compostela, Facultade de Ciencias, Campus de Lugo, 27002 Lugo, Spain

Abstract: We report that the clinically used antitumor drug mitomycin C is reductively activated in vitro by simple thiols; a mechanism for this activation is proposed based on kinetic data and the identification of mitosene metabolites. The biological implications of these findings are discussed.