Please login first
Comparison of the metabolomic signature of diabetes and the oral glucose tolerance test
1, 2 , 1, 2 , * 3
1  Department of Pediatrics, Hospital Universitario Puerta del Mar. Cádiz, 11009, Spain
2  Institute of Research and Innovation in Biomedical Sciences of the Province of Cádiz (INiBICA), Cádiz, Spain
3  Department of Chemistry, Faculty of Experimental Sciences. University of Huelva, Spain.

Published: 31 October 2018 by MDPI in 4th International Electronic Conference on Medicinal Chemistry session ECMC-4

Intervention trials attempt to clarify the possible effects of certain challenge tests on study subjects (e.g. drugs effectiveness, environmental exposure experiments), while observational studies employ free-living populations to analyze the relationship between a particular effect and possible triggering factors. Based on the hypothesis under investigation, the researcher will choose the appropriate study design. Nevertheless, here we report the utility of combining observational and interventional studies to discover confident biomarkers in the clinical field (1). We contrasted metabolomic profiles related with diabetes and the oral glucose tolerance test (OGTT), a clinical test used to simulate the hyperinsulinemia observed in diabetes. We found that the main metabolic changes occur in the same metabolite classes, including energy-related metabolites, amino acids (especially brain chain amino acids, BCAA) and multiple lipids, such as free fatty acids, acyl-carnitines, triglycerides and phospholipids, among them. Hence, challenge tests such as the OGTT guarantee to be a great strategy to investigate pathological signatures associated with the development of diseases as a previous step before performing validation works in observational studies.

(1) Á. González-Domínguez, A.M. Lechuga-Sancho, R. González-Domínguez. Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test. Curr. Top. Med. Chem. 18 (2018) 896-900

Keywords: metabolomics; diabetes; oral glucose tolerance test