Antibacterial activity of cyclam derivatives

João Portel; Luis Alves; Sílvia Sousa; Jorge Leitão; Ana Martins

doi:10.3390/ecmc-4-05595

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Antibacterial activity of cyclam derivatives

João F. Portel

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¹ Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
² iBB - Instituto de Bioengenharia e Biociências, Instituto Superior Técnico, Universidade de Lisboa Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
³ Centro de Química Estrutural, Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Av. Rovisco Pais 1, 1049-003 Lisboa, Portugal

Published: 31 October 2018 by MDPI in 4th International Electronic Conference on Medicinal Chemistry session Posters

https://doi.org/10.3390/ecmc-4-05595

Abstract:

The steadily increasing of the resistance of human pathogens to multiple antimicrobials over the last decade is alarming and a serious threat to public health.[1] While the emergence of multidrug resistance has been associated with misuse and abuse of antimicrobials, the number of available effective agents is decreasing as novel compounds arriving into the market are scarce.[2,3]

Tetraazamacrocycles are versatile and readily tunable molecules with potential for the development of derivatives having enhanced antimicrobial activity. Our recent work led to the identification of cyclam derivatives as a potential novel class of compounds that represents a breakthrough in the field of new antibacterial drugs.[4]

[1] WHO. Antimicrobial Resistance: Global Report on Surveillance 2014; Geneva, 2014

[2] Bax, R.; Mullan N.; Verhoef, J., Int. J. Antimicrob. Agents 2000, 16, 51-59

[3] Norrby, S. R.; Nord, C. E.; Finch, R., Lancet Infect. Dis. 2005, 5, 115-119

[4] Alves, L. G.; Pinheiro, P. F.; Feliciano, J. R.; Leitão, J. H.; Martins, A. M., Int. J. Antimicrob. Agents 2017, 49, 646-649

Keywords: Cyclams, Azamacrocycles, Antimicrobials, Bacteria

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Comments on this paper

Sarah Khan

8 December 2018

Numerous medication opposition

Numerous medication opposition (MDR), multidrug obstruction or multi-opposition is antimicrobial opposition appeared by a type of microorganism to different antimicrobial medications. Whey protein in Pakistan. The sorts most compromising to general wellbeing are MDR microscopic organisms that oppose numerous antimicrobials.

João Portel