Study on the synthesis of some (un)substituted 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles in the water medium

¹ Faculty of Chemistry, VNU Hanoi University of Science, 19 Le Thanh Tong, Hanoi (Vietnam)
² Institute of Technique in Chemistry, Biology and Security Documents (Ministry of Public Security, Vietnam)
³ Faculty of Chemistry, VNU University of Science (Vietnam National University, Ha Noi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam
⁴ Institute for Chemistry and Materials, Military Institute of Science and Technology, 17 Hoang Sam, Cau Giay, Ha Noi, Viet Nam
⁵ Viet Tri University of Industry, Tien Kien, Lam Thao, Phu Tho, Viet Nam

Published: 14 November 2018 by MDPI in The 22nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-22-05665

Abstract:

An efficient and simple synthesis of substituted 2-amino-4H-chromene-3-carbonitriles was developed by the one-pot and three-component reaction of a mixture of corresponding substituted benzaldehydes, resorcinol, and malononitrile in the presence of sodium carbonate solution as a catalyst at room temperature.

Keywords: 2-amino-4H-chromene-3-carbonitriles; propargyl ethers; potassium carbonate; SN2

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