An efficient and simple synthesis of substituted 2-amino-4H-chromene-3-carbonitriles was developed by the one-pot and three-component reaction of a mixture of corresponding substituted benzaldehydes, resorcinol, and malononitrile in the presence of sodium carbonate solution as a catalyst at room temperature.
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Study on the synthesis of some (un)substituted 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles in the water medium
Published: 14 November 2018 by MDPI in The 22nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: 2-amino-4H-chromene-3-carbonitriles; propargyl ethers; potassium carbonate; SN2